Latent viral infections as neglected risk factors for long COVID
Abbreviations em : Emission wavelength ex : Excitation wavelength Z score: Delta Z score ATF4: Activating transcription factor 4 BAT: Brown adipose tissue BPTES: Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide BS: Beam splitter BTHS: Barth syndrome CCCP: Carbonyl cyanide m -chlorophenyl hydrazone CL: Cardiolipin CT: Computed tomography DEG: Differentially expressed gene 2DG: 2-Deoxy-d-glucose Doxy: Doxycycline DTT: Dithiothreitol ECAR: Extracellular acidification rate ECM: Extracellular matrix eIF2: Eukaryotic initiation factor 2 alpha subunit ER: Endoplasmic reticulum [ 18 F]FDG: [ 18 F]Fluorodeoxyglucose FGF-21: Fibroblast growth factor 21 FPKM: Fragments per kb of transcript per million mapped reads Fura-2AM: Fura-2 acetoxymethyl ester GDF-15: Growth differentiation factor 15 O -GlcNAc: O -linked - N -acetylglucosamine GO: Gene ontology G6PDH: Glucose 6-phosphate dehydrogenase GSIS: Glucose-stimulated insulin secretion HTRF: Homogeneous time-resolved fluorescence IHC: Immunohistochemistry ISR: Integrated stress response KHB: KrebsHenseleit buffer LAMP1: Lysosomal-associated membrane protein 1 LAMP2: Lysosomal-associated membrane protein 2 LC3B1: Microtubule-associated protein 1 light chain 3 beta (cytosolic) LC3B2: Microtubule-associated protein 1 light chain 3 beta (membrane-bound) Mito-roGFP2-Orp1: Mitochondria-redox-sensitive green fluorescent protein 2oxidant receptor peroxidase 1 NAD(P)H: NADH/NADPH OCR: Oxygen consumption rate OCT: Optimal cutting temperature PC: Phosphatidylcholine PE: Phosphatidylethanolamine PET: Positron emission tomography PFA: Paraformaldehyde PG: Phosphatidylglycerol PINK1: PTEN-induced putative kinase 1 Prk8: Parkin Prx3: Peroxiredoxin 3 P/S: Penicillin/streptomycin roGFP2-Orp1: Redox-sensitive green fluorescent protein 2oxidant receptor peroxidase 1 ROS: Reactive oxygen species shRNA: Short hairpin RNA SRC: Spare respiratory capacity STED: Stimulated emission depletion Taz: Tafazzin Taz -KD: Taz knockdown TMRM: Tetramethylrhodamine methyl ester wo: Week(s) old WT: Wild-type References Dudek J, Maack C (2017) Barth syndrome cardiomyopathy
In this phase, the liver attaches a glutathione molecule to a toxin, making that toxin water-soluble so it can be safely flushed out of the body through the kidneys or gut
Wang F, Li Y, Shen Y, Wang A, Wang S, Xie T
Targeting bioenergetics prevents CD4 T cell-mediated activation of synovial fibroblasts in rheumatoid arthritis
